Alpha-1-Antitrypsin (AAT) Pipeline
AAT
- A naturally occurring anti-inflammatory protein
- FDA approved and prescribed for emphysema and chronic obstructive pulmonary disorder (COPD) in AAT- deficient patients.
- Inhibits destructive enzymes such as proteinase-3
- Anti-complement
- Prevents maturation of antigen presentation
- Induces T-regulatory cells
- Inhibits responses to inflammatory cytokines
Type 1 Diabetes
Omni Bio is currently a sponsor of a 15 patient clinical trial for recently diagnosed Type1 diabetics being conducted at the Barbara Davis Center for Childhood Diabetes at the University of Colorado Denver Anschutz Medical Campus. Under an IND granted by the FDA, we may increase the patient size of the trial up to 50 patients.
Scientific Research
Historically, Omni Bio has conducted its AAT research through sponsored research agreements (SRAs) with UCD. In early 2010, we completed an SRA in the area of bacterial disorders Recently, we completed an additional SRA in the area of diabetes.
Omni Bio has letter of intent to commence human clinical trial in GVHD.
Recent Publications
Dr. Dinarello Awarded the Paul Ehrlich Prize
02-Oct-2009 - Dr. Charles A. Dinarello of the University of Colorado and Acting CEO of Omni Bio Pharmaceutical to be Awarded the Paul Ehrlich Prize
Acquisition of Apro Bio Pharmaceutical
20-Apr-2009 - Across America Financial Services Completes Acquisition of Apro Bio Pharmaceutical Corporation
Alpha-1-Antitrypsin is an endogenous inhibitor of proinflammatory cytokine
05-Feb-2009 - Alpha-1-Antitrypsin is an endogenous inhibitor of proinflammatory cytokine production in whole blood. The Journal of Leukocyte Biology, Gregory B. Pott, Edward D. Chan, Charles A. Dinarello, and Leland Shapiro
15-Dec-2008 - Keeping Diabetes ATT Bay, Nature Biotechnology, Peter Hare
A tolerant alternative to immunosuppression
06-Nov-2008 - A tolerant alternative to immunosuppression, Science-Business eXchange, Kai-Jye Lou
AAT Could Overcome Obstacles To Islet Transplantation
30-Oct-2008 - Well-known Drug (AAT) Could Overcome Obstacles To Islet Transplantation, Study Suggests, Science Daily
Curative and Beta cell regenerative effects of AAT
13-Oct-2008 - Curative and Beta cell regenerative effects of alpha 1-antitrypsin treatment in autoimmune diabeticNOD mice, PNAS, Maria Koulmanda, Manoj Bhasin, Lauren Hoffman, Zhigang Fan, Andi Qipo, Hang Shi, Susan Bonner-Weir, Prabhakar Putheti, Nicolas Degauque, Towia A. Libermann, Hugh Auchincloss Jr., Jeffrey S. Flier, and Terry B. Strom
α1-Antitrypsin monotherapy induces immune tolerance
13-Oct-2008 - α1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice (10/13/08) PNAS, Eli C. Lewis, Mark Mizrahi, Michel Toledano, Nathaniel DeFelice, Joanne L. Wright, Andrew Churg, Leland Shapiro, and Charles A. Dinarello
Association between Type 2 diabetes and Alpha-1-antitrypsin deficiency
15-Jan-2008 - An association between Type 2 diabetes and Alpha-1-antitrypsin deficiency, Diabetic Medicine, C. S. Sandström, B. Ohlsson, O. Melander, U. Westin, R. Mahadeva and S. Janciauskiene
AAT anomalies associated with lung disease
06-Sep-2005 - Alpha-1-antitrypsin (AAT) anomalies are associated with lung disease due to rapidly growing mycobacteria and AAT inhibits Mycobacterium abscessus infection of macrophages (1/01/07) Scandinavian Journal of Infectious Diseases, EDWARD D. CHAN, ALEKSANDRA M. KAMINSKA1, WENDY GILL, KATHRYN CHMURA, NICOLE E. FELDMAN, XIYUAN BAI, CORINNE M. FLOYD, KAYTE E. FULTON, GWEN A. HUITT, MATTHEW J. STRAND, MICHAEL D. ISEMAN & LELAND SHAPIRO
Saving islets from allograft rejection
06-Sep-2005 - Saving islets from allograft rejection, PNAS, Terry B. Strom
Improving graft survival in islet transplantation
23-Aug-2005 - Improving graft survival in islet transplantation, PNAS, EZ
α1-Antitrypsin monotherapy prolongs islet allograft survival
23-Aug-2005 - α1-Antitrypsin monotherapy prolongs islet allograft survival in mice (8/23/05) PNAS, Eli C. Lewis, Leland Shapiro, Owen J. Bowers, and Charles A. Dinarello
Alpha-1-antitrypsin inhibits human immunodeficiency virus type 1
15-Jan-2001 - Alpha-1-antitrypsin inhibits human immunodeficiency virus type 1, FASEBJ, LELAND SHAPIRO, GREGORY B. POTT, AND ANNEMARIE H. RALSTON
